Preheat oven to 350 degrees F and line a baking sheet with parchment paper.
Cream butter and sugar together in a large bowl with a hand mixer on medium speed.
Beat in eggs and ricotta cheese and anisette until smooth.
Mix in vanilla and orange zest until blended.
Whisk together flour, baking powder, baking soda, and salt in a separate bowl.
One cup at a time, add dry mixture into the wet mixture until the dough is formed.
Drop a heaping tablespoon of dough for each cookie onto the prepared baking sheet and bake for 10 to 12 minutes.
Allow to cool slightly before transferring to a wire cooling rack to cool completely.