Combine the flour, baking powder, cinnamon, baking soda and salt in small bowl.
Beat butter and sugar in large mixer bowl until creamy.
Add eggs one at a time, beating well after each addition.
Beat in pumpkin and vanilla extract. Gradually beat in flour mixture. Spoon half of batter into the prepared baking dish.
Sprinkle 3/4 cup Streusel Topping over batter.
Spoon remaining batter evenly over Streusel Topping; sprinkle with remaining Streusel Topping. Bake the coffee cake for 45 to 50 minutes or until a toothpick inserted in center comes out clean. Cool in pan on wire rack for 10 minutes; remove to wire rack to cool completely.